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TY - JOURT1 - Carbon dating cancer T2 - Annals of Oncology AU - Lote, H. KW - Cancer evolution KW - Metastatic colorectal carcinoma KW - Mutational analysis KW - Phylogenetic tree KW - Synchronous metastases KW - Whole genome sequencing UR - / Lote, H.; Spiteri, I.; Ermini, L.; Vatsiou, A.; Roy, A.; Mc Donald, A.; Maka, N.; Balsitis, M.; Bose, N.; Simbolo, M.; Mafficini, A.; Lampis, A.; Hahne, J. Lote, H, Spiteri, I, Ermini, L, Vatsiou, A, Roy, A, Mc Donald, A, Maka, N, Balsitis, M, Bose, N, Simbolo, M, Mafficini, A, Lampis, A, Hahne, JC, Trevisani, F, Eltahir, Z, Mentrasti, G, Findlay, C, Kalkman, EAJ, Punta, M, Werner, B, Lise, SLote, H. Neo-antigen analysis suggested minimal immunogenicity. Conclusion: Our data provide the first in vivo experimental evidence documenting the timing of metastatic progression in CRC and suggest that genomic instability might be more important than themetastatic potential of the primary cancer in dictating CRC fate. Make yourself comfortable in our main lobby, where lavish furnishings welcome you to sit back and relax.Take in the beauty of the surrounding mountains with floor to ceiling windows that line our Grand Ballroom, suited for up to 360 guests.

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The thyroid lesion presented as a tumour-to-tumour deposit within a benign Hurthle adenoma.

The primary tumour metastasized to the lung and the thyroid within a year from its onset.




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